The large public health impact of protective biofilms built by bacteria is not as well-known is it could be. NIH considers biofilms implicated in up to 80% of chronic infections, and Staph bacteria such as MRSA are major players in the biofilm arena. These realities underline the importance of the natural products chemistry reported here (a semi-synthetic derived from a sponge extract) and discovery of teixobactin realised thru the revolutionary “iChip” technique for growing natural environment bacteria under lab conditions (http://tinyurl.com/pb58d8x).